Probably. With a custom computer/self-built you'd need the license/Product Key but with an OEM the Win10 license is part of the BIOS, started with Win8 and continues into Win11. The change of the motherboard is different and if it doesn't activate Windows after install there usually are alternative ways to do it such as a phone call to Microsoft, number provided, or maybe a different online choice. I haven't done a System Builder version since Win7 so am not familiar with any changes in that process.