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It seems that Microsoft has decided to remove this registry key and the ability to manually disable Windows Defender
SOURCE: https://docs.microsoft.com/en-au/wi...y-malware-windows-defender-disableantispywareDisableAntiSpyware is intended to be used by OEMs and IT Pros to disable Microsoft Defender Antivirus and deploy another antivirus product during deployment. This is a legacy setting that is no longer necessary as Microsoft Defender antivirus automatically turns itself off when it detects another antivirus program. This setting is not intended for consumer devices, and we’ve decided to remove this registry key.