I have that Corel photo program too.
It does the same thing to me as well, around 10% of the time.
Instead of restarting, I use Task Manager to kill it, then double click the program icon, and it works again.
Used to work fine before upgrading to Windows 10.
X2 is old, so good luck with getting an update to fix it.
I have Paint Shop Pro X, and it works on Windows 10 no problems.
I only use X2 for the digital noise reduction effect. I use Adobe Photoshop Elements 5.0 more these days,
even though it's old as well, it keeps working on Windows 10 without any problems.
I will definitely try "Compatibility mode" the next time X2 does not open.
I see Jamma had the same problem as well back in 2016