The only issue is that usually FAT32 is required for some booting, the MCT/Media Creation Tool wipes the drive and reformats as FAT32. Windows has a limit of 32GB drive or partition size for FAT32 and single file size of 4GB, exFAT doesn't. My last 2 4TB External USB HDDs came as exFAT so as to be usable on PC or Mac, mentioned on the package/box, Mac has issues with writing NTFS drives.