This is VERY old thread. but, no - I think it happens only if the OS finds itself on a different SSD or HD, or if it noticed the mobo has been changed - like different chipset - it's looking for things that would indicate it had been illegally cloned/copied and was now somewhere else than when it had been activated. Memory updates happen constantly and would be no cause (to it) for concern. Folks like me often change SSD, and/or mobo, but still keep only 1 copy active for that key, so have to call in and have it manually re-keyed over the phone, but I think they have automated even more of that process lately. But I got rid of the box and just using laptops and tend to use the key on the bottom of it, or buy a cheap retail key on ebay that I can easily re-use/make hardware changes. But I always play it legal - one OEM key per mobo, unless go through phone activation because the previous one burnt up (I have fried mobos). Whatever you do, just be legal - do the phone thing!
If you lost your key, just buy a cheap retail key on ebay and use that. That's what I did when I wanted to move win7 and wanted to play with win10 for a bit. I keep paper copies and photo copies of keys so I don't lose them. I run Ubuntu 18.10,but constantly change it, and having a retail key for win7 which is on the same SSD means I don't have to worry if the SSD or laptop bites the dust. I used to have a strip of legal OEM COA's lying around, but more and more, MS is not allowing them, esp as win7 gets close. The cheap retail win7 key solves all that. I think my spare laptop is using an old OEM key, but I haven't powered it up since I got this T530 and the retail key for it.
