I am, unfortunately, a dedicated and obsessed tester. This thread drew me in.
I ran Ccleaner. Usual results. I did not run the registry cleaner.
Ran ADwCleaner three times, with the requested reboot. Each time, although I complied with the request to clean, it did not clean three Pups, which it discovered in the registry - not unexpected, I test plenty of third party progs, which often have a dirty uninstall..
Ran Malwarebytes (Free). It found the same Pups and, on request, cleaned them.
Ran ADwCleaner again and it, then, found nothing.
I think it is possible that Ccleaner, if I had selected the option, would have found the registry Pups
I don, on principal, normallyy interfere with the registry, except to manually remove uninstalled third party progs from the "Software" section.
So, my own conclusion is I'll stick to what works for me.
Needed to add: I noticed on the bottom of the Malwarebytes ADware was a recommendation that you try Malwarebytes free!