Windows 10 has all sorts of issues recognizing my Seagate using the USB 3 port. If it's a USB 3 device, try a regular USB 2 port. Usually rebooting with the drive plugged in to the USB 3 port, Windows will recognize it. In an emergency, the drive inside the enclosure is a regular sata drive, and can be installed in a desktop PC if you break open the enclosure.