I took the cover off this afternoon and gave it a good blow out
Probably the most important thing you can do, if you are going to leave the computer running all the time.
To share a personal anecdote from my own experience....
A few years back, I got a call from a client, a local GM new car dealership. When I arrived I was lead to one of the workstation desks in the large floor room sales area to see what looked mostly like a tower PC but it was covered in white / grayish dust. The contents of a fire extinguisher or at least most of it had been emptied at it.
Long story short.... dust bunnies had accumulated in the power supply and had somehow ignited, resulting in a fire.
Fortunately it was during their hours of operation and someone was alert enough to notice the smoke coming from under the desk.
I don't think that a lot of quality control goes into the manufacture of most power supplies you find installed in a lot of the big box store purchases of PCs.
For some reason I imagine them being made somewhere in huge buildings, where people work for a few dollars a day, that have suicide netting around the exterior.
IF.... "made in china" hover boards and cellphone battery boosters can spontaneously burst into flames, why should your power supply which is likely made in the same building or next door, be any different.
Especially if you feed it some dandy dust bunny tinder to aid the process.
You can leave your computer on 24 / 7 if you want, but personally.....
IF I ain't home, it's off, and that includes the power strip between it and the wall.