Assuming you are referring to using the Mail app in Windows 10.
The answer is :
Not with that bush-league Mail app that is included with Windows 10.
excerpt: Source Can I create new folders or delete old folders in the Mail app?
I've been asked this question quite a bit more than I expected, and the plain answer is 'No.' It's not possible to use the Windows 10 Mail app to create new folders or to delete folders for your email account. You have to create or delete folders using either the web interface or another email client (Outlook if using a company Exchange account) and then they will show up automatically in the Windows 10 Mail app.
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